Smithville, in Monroe County, had its beginning on December 3, 1836, when a Chickasaw signer of the Treaty of Pontotoc, named Co Chubby on the town's marker and Che-lah-cha-chubby by Wikipedia, sold the land to James D. Couch. About 1840 William Smith bought land here and built a log house and store, and the village was surveyed around his home. Early settlers included William and Cornelius Dowd, Zachariah Wall, Henry Stegall, two doctors and the Cheek and Cowley families, and the Smithville landing on the Tombigbee was the town's main link to the outside world before the railroads.
More about Smithville
Sources differ on the charter date, 1845 or 1846; a post office opened on June 8, 1846. Local men joined the "Red Rovers," Company A of the 5th Mississippi Infantry, mustered in at Athens on April 27, 1861. The short-line Mississippian Railroad, built in 1921 mainly for logging, ran from Amory to Fulton through Smithville. With Aberdeen, it is one of Monroe County's two surviving antebellum towns.
At about 3:45 p.m. on April 27, 2011, an EF5 tornado with winds estimated at 205 miles per hour struck Smithville, killing 16 people and injuring 40, and destroying the city hall, post office, police station and four churches.
Sources
The Historical Marker Database: Town of Smithville (Dalrymple Family Foundation)
Wikipedia: Smithville, Mississippi