When the Plymouth Colony was founded in 1620, the area was home to the Pocasset Wampanoag, part of the Pokanoket Confederacy centered at Mount Hope in present Bristol, Rhode Island. The city's name refers to the Quequechan River, a Wampanoag name believed to mean "falling river," which drops through the city into the bay. In 1653 members of the Massachusetts Bay Colony settled Freetown, whose Freeman's Purchase included the northern part of present Fall River, and Freetown was incorporated in 1683. The southern part became the town of Tiverton in 1694, and in 1746 a boundary settlement gave Tiverton to Rhode Island, placing the line near today's Columbia Street.
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In 1703 Benjamin Church, a hero of King Philip's War, built a sawmill, gristmill and fulling mill on the Quequechan, and in 1714 he sold the land and its water rights to Richard Borden of Tiverton and his brother Joseph, a purchase that a century later helped make the Borden family leaders of the city's textile industry. In the 18th century the area was mostly small farms. In 1778, during the Revolution, after British raids had badly damaged Bristol and Warren, the local militia put up a strong defense against a British force at the Battle of Freetown.
Fall River was separated from Freetown and incorporated as a town in 1803. A year later it changed its name to Troy, which it kept for 30 years until changing back to Fall River on February 12, 1834. It became a city in 1854, and the Fall River Female Anti-Slavery Society was formed in 1835. In the 1960s Interstate 195 was built along the Quequechan, partly underground.
Sources
Wikipedia: Fall River, Massachusetts