The Nipmuc lived in the area, which they called Quinsigamond, and had a settlement on Pakachoag Hill in present Auburn. In 1673 John Eliot and Daniel Gookin led an expedition there to found a Christian Indian "praying town" and to find a site for an English settlement, and on July 13, 1674, Gookin obtained a deed to eight square miles. When King Philip's War broke out in 1675, the Nipmuc joined Metacom's side, the English abandoned Quinsigamond, and its empty buildings were burned. The settlement was abandoned again during Queen Anne's War in 1702.
More about Worcester
Jonas Rice resettled the town for good in 1713. Named for Worcester, England, it was incorporated on June 14, 1722, and became the seat of the new Worcester County on April 2, 1731. John Adams taught school and studied law in Worcester from 1755 to 1758.
On September 6, 1774, 4,622 militiamen from 37 towns in Worcester County marched on Main Street and seized the courthouse to keep the royal court from sitting. The Crown's 25 appointees were turned away and made to renounce their commissions, without a shot fired. This Worcester Revolt is described as the first time British authority was openly overthrown in the colonies. In 1775 the printer Isaiah Thomas moved his radical newspaper, the Massachusetts Spy, from occupied Boston to Worcester and kept it running through the war. On July 14, 1776, Thomas gave the first public reading of the Declaration of Independence in Massachusetts.
Sources
Wikipedia: Worcester, Massachusetts